UP TO 93% OF PATIENTS DEVELOP ADHESIONS FOLLOWING INITIAL LAPAROTOMY1,2
What are Adhesions?
Adhesions are fibrinous bands of internal scar tissue that can cause internal tissues and organs that are normally separated to stick together.5 They are a common complication in abdominal surgery.3,4 Adhesions are reported to cause:*
- Short- and long-term patient morbidities, including small bowel obstruction (SBO)3,5
- Surgical complexity during reoperation3
- Economic burden for patients, third-party payers, and society as a whole3
*Note: Seprafilm is not indicated for the reduction of adhesion-related complications.
How Adhesions Form
The images herein depict the 7-day post-surgical healing period during which new adhesions can form.
The 7-day Adhesion Formation Period
Potential Causes of Adhesions
Adhesion formation is a complex biological process triggered by an inflammatory response to trauma and a prolonged suppression of fibrinolytic activity following peritoneal injury. Common causes of adhesions include:1,3
- Tissue manipulation
- Heat or electrocautery
- Foreign particles
- Factors causing tissue damage
Because adhesion formation is the body’s natural response to tissue trauma, unfortunately, even meticulous surgical technique alone is not adequate to prevent adhesions.3
Adhesion Treatment and Prevention
Currently there is no treatment for adhesions; some complications from adhesions may require adhesiolysis (the removal of existing adhesions), which may result in additional adhesions. Unfortunately, meticulous surgical technique alone is not enough to prevent adhesions. As such, adhesion barriers may be placed prophylactically during surgery to reduce the incidence and severity of adhesions before they form.3