To order Seprafilm or for more information, call 1-800-261-1570 Instructions for Use (IFU)
For US Healthcare Professionals Only


Seprafilm Adhesion Barrier is contraindicated in patients with a history of hypersensitivity to Seprafilm and/or to any component of Seprafilm. Seprafilm Adhesion Barrier is contraindicated for use wrapped directly [...]
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For US Healthcare Professionals Only

About Seprafilm

Seprafilm is a mechanical bioresorbable adhesion barrier that is applied to adhesiogenic tissues before surgical closure. It is indicated for the reduction in the incidence, extent, and severity of postoperative adhesions in patients undergoing abdominal or pelvic laparotomy.1

Clinical Trial and Patient Experience

Seprafilm has been FDA approved as an adhesion barrier since 1996. To support approval, Seprafilm Adhesion Barrier was studied in five clinical trials involving 2,133 patients.1

More than 4 million patients have received Seprafilm in clinical use worldwide.2

Mode of Action (MOA)

When placed between traumatized tissue surfaces, Seprafilm acts as a physical barrier preventing the formation of adhesions between opposing tissues while the natural process of tissue wound healing takes place. Seprafilm turns into a gel that is reabsorbed into the body.1,3

  • Composition: Seprafilm is comprised of two anionic polysaccharides: modified hyaluronic acid (HA) and carboxymethylcellulose (CMC).3
  • Residence time: Seprafilm turns into a gel within 24-48 hours after placement and stays in place for up to seven days—the critical tissue healing period. By day 7, Seprafilm is resorbed from the abdominopelvic cavity and, by day 28, Seprafilm is excreted from the body.1,3
  • Characteristics: Seprafilm is sterile, bioresorbable, translucent, and hydrophilic.1

Seprafilm Safety and Efficacy

For detailed Seprafilm efficacy and safety data, click here.

Seprafilm offers an effective and safe method for reducing postsurgical adhesions:

  • Indicated for the reduction of the incidence, extent, and severity of adhesions1
  • The only FDA-approved adhesion barrier indicated for both abdominal and pelvic laparotomy1
  • Safety and efficacy has been established by prospective randomized trials in abdominal and pelvic surgery3,4

The safety and effectiveness of Seprafilm Adhesion Barrier has not been evaluated in clinical studies for the following involving: Patients with frank infections in the abdominopelvic cavity, patients with abdominopelvic malignancy, device placement in locations other than directly beneath an abdominal wall incision following laparotomy, or directly on the uterus following open myomectomy (not laparoscopic), patients with ongoing local and/or systemic inflammatory cell responses, device use in the presence of other implants, e.g. surgical mesh, patients requiring re-operation within 4 weeks of Seprafilm placement – during anticipated time of peak adhesion formation as is associated with natural progression of healing.


  1. Seprafilm® Adhesion Barrier Instructions for Use (IFU); Genzyme Corporation, Cambridge, MA; 2017.
  2. Data on file. Genzyme Corporation. Cambridge, MA: Genzyme Corp.
  3. Becker JM, Dayton MT, Fazio VW, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg. 1996;183(4):297-306.
  4. Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG; for Adhesion Study Group Steering Committee. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm® adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum. 2003;46(10):1310-1319.