To order Seprafilm or for more information, call 1-800-261-1570 Instructions for Use (IFU)
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For US Healthcare Professionals Only

IMPORTANT SAFETY INFORMATION

Seprafilm should not be wrapped around an intestinal anastomosis as such usage may result in increased anastomotic leak-related events, such as abscess or peritonitis. The safety and effectiveness of Seprafilm [...]  View Full Important Safety Information

For US Healthcare Professionals Only

Seprafilm Application Techniques1

Click here to view the Directions for General Use

A variety of application techniques may help with successful Seprafilm placement, as follows.

  • Seprafilm may be cut, shaped, and handled in various ways
  • Keep retractor in place
  • Create good skin retraction by pulling up and out with retractor
  • The membrane should be handled gently with dry instruments and/or gloves

Abdominal Seprafilm Application Techniques

Cut full sheet in half. Slightly curve edges upward into taco shape. Pull back bottom piece 1-2 cm to expose leading edge of taco.

Guide through incision and touch leading edge on manipulated tissue. While gently pressing the membrane down with a dry glove or sponge stick, withdraw the bottom holder and then top holder.*

Remove one layer of the holder. Slide the holder back 1-2 cm to expose a leading edge. Curve edges to form a cigar shape with the holder in place.

Guide through incision and touch leading edge on manipulated tissue. Release and allow the membrane to unroll. While gently pressing the membrane down with a dry glove or sponge stick, withdraw the holder.*

Remove top layer of holder. Slide the holder back 1-2 cm to expose a leading edge. Slightly curve edges upward.

Guide through incision. While gently pressing the membrane down and forward with a sponge stick, withdraw the bottom layer of the holder.*

Remove top layer of holder. Slide the holder back 1-2 cm to expose a leading edge. Slightly curve edges upward.

Guide through incision. While gently pressing the membrane down and forward with a sponge stick, withdraw the bottom layer of the holder.*

Slide holder back 1-2 cm to expose a leading edge. Slightly curve edges upward.

Using a dry glove, guide Seprafilm through incision. While gently pressing membrane down, remove bottom holder and then top holder. Repeat to form a flower shape.*

*Repeat as necessary to extend Seprafilm sufficiently beyond the margins of incision and associated trauma. When necessary, lightly moisten membrane with standard irrigation solution to facilitate coverage around the contours of tissues and organs.

The safety and efficacy of Seprafilm adhesion barrier has not been evaluated in clinical studies in the presence of malignancies in the abdominopelvic cavity.

Abdominal Seprafilm Application Sites

Seprafilm serves as a temporary bioresorbable barrier separating apposing tissue surfaces and can be placed between the abdominal wall and the underlying viscera, including the:

  • Omentum
  • Small bowel
  • Bladder
  • Stomach

Seprafilm Adhesion Barrier should not be wrapped directly around a fresh anastomotic suture or staple line.

Pelvic Seprafilm Application Techniques

Full sheet cut in half

Cut full sheet in half lengthwise starting at the handle. Pull back bottom holder 1-2 cm to expose leading edge. Slightly curve edges upward.

Touch leading edge of membrane on one side of the hysterotomy. While gently pressing the membrane down with a dry glove or sponge stick, withdraw the bottom holder and then the top holder. Touch leading edge of remaining membrane at the top of the fundus and overlap with the other membrane to form a “T” shape.*

4-Section with holder

Fold back the tabbed holder and expose a leading edge of Seprafilm with the tab on the bottom.

Touch exposed edge of membrane horizontally across the hysterotomy and pull tab to remove holder. Repeat for other side of hysterotomy and then place two membranes up the fundus, starting at the hysterotomy to form an inverted “T” shape.*

4-Section without holder

Remove membrane from holder with dry glove. Curve membrane and grasp with pickups.

Touch exposed edge of membrane horizontally across the hysterotomy. Repeat for other side of hysterotomy and place two membranes up the fundus, starting at the hysterotomy to form an inverted “T” shape.*

Full sheet when the uterus is externalized

Fold back bottom holder to expose leading edge of membrane. Slightly curve edges upward.

Touch leading edge of membrane over the fundus and gently mold down to the hysterotomy. Remove bottom holder. Lightly moisten membrane with standard irrigation solution. A moist lap can be used to press and adhere the membrane to tissue surface and then remove top holder. The moist lap can be used to cover the Seprafilm surface area to protect the Seprafilm from adjacent tissue when the uterus is internalized.*

*Repeat as necessary to extend Seprafilm sufficiently beyond the margins of incision and associated trauma. When necessary, lightly moisten membrane with standard irrigation solution to facilitate coverage around the contours of tissues and organs.

Seprafilm is not recommended for use during pregnancy and avoidance of conception should be considered during the first complete menstrual cycle after use of Seprafilm Adhesion Barrier.

Pelvic Seprafilm Application Sites

Seprafilm serves as a temporary bioresorbable barrier separating apposing tissue surfaces and can be placed between the uterus and surrounding structures, including the:

  • Tubes and ovaries
  • Large bowel
  • Bladder

References

  1. Seprafilm® Adhesion Barrier Instructions for Use (IFU); Genzyme Corporation, Cambridge, MA; 2008.